Endocrine Abstracts

Introduction: Sheehan’s syndrome (SS) is a rare complication of postpartum hemorrhage resulting in varying degrees of pituitary insufficiency. The diagnosis of SS has often been overlooked and thus delayed for many years due to its nonspecific signs and symptoms. Lymphocytic hypophysitis (LL) is also an uncommon autoimmune disorder that has to be suspected in women with recent delivery presenting with changes of one or more pituitary hormone secretions, especially when as...

Introduction: Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of adrenal steroidogenesis, generally caused by total or partial deficiency in 21-hydroxylase, due to deletions or mutations of CYP21 gene. Some studies suggest that the association between CAH and multiple sclerosis (MS) could be nonincidental: a possible MS susceptibility locus is on chromosome 6p21, on which the CYP21 gene is located.We report the c...

Introduction: Thyroid disorders are common within the elderly population and are particularly challenging to diagnose and treat due to the presence of a wide variety of comorbidities. Graves’ ophtalmopathy remains a therapeutic predicament despite all progress made in understanding its pathogenesis, especially in the elderly population with severe presentation.Case presentation: We present the case of a 71-years-old female patient who was admitted i...

Introduction: Morbidly obese patients raise many problems in therapeutic attitude, sometimes associating a cluster of obesity-related abnormalities: hypogonadotropic hypogonadism, metabolic syndrome, respiratory insufficiency, and high risk for cardiovascular disease. These afflictions can be reversed through weight loss, especially in young patients.Case presentation: We present the case of a 41 year old male patient, smoker, with morbid obesity (BMI =6...

Introduction: Ophthalmopathy, the most common extrathyroidal manifestation of Graves’ disease, occurs in 5% of cases in the absence of hyperthyroidism. Amiodarone, an iodine-rich antiarrhythmic drug, influences thyroid function, causing thyrotoxicosis or hypothyroidism, but its effect on thyroid autoimmunity is still a matter of debate.Case report: We report the case of a 58-year-old woman, suffering from non-sustained ventricular tachycardia, treat...

Introduction: Obesity is generally associated with a chronic state of subclinical inflammation. The assessment of the inflammatory status is routinely made by measuring circulating levels of nonspecific proinflammatory markers. Neutrophil to lymphocyte ratio (NRL) is a new simple inflammatory marker which can be reliable in evaluating the inflammatory status occurring in morbidly obese patients. The aim of this study was to investigate the relationship between NLR as an index ...

Introduction: Central diabetes insipidus is a rare, chronic disease characterized by polyuria and polydipsia due to a partial or total vasopressin deficiency (hypothalamic – neurohypophysial system damage). The aetiology can be familial (autosomal dominant inheritance, X-linked recessive traits; mutation of the vasopressin – neurophysin II genes), secondary (tumours, infections, infiltrative diseases, trauma, vascular lesions) and idiopathic (10–30%).<p clas...